Protein Folding and Conformational Diseases

Investigador/s Principal/s :

Salvador Ventura
salvador.ventura@uab.es

Departament:

Proteómica Aplicada e Ingeniería de Proteínas

Centre:

Institut de Biotecnologia i Biomedicina

Institució:

UAB (Universitat Autònoma de Barcelona)

Membres: 6

Línia de recerca:

Our research interests are protein folding, misfolding and amyloid formation, with special focus on their role in conformational diseases such as Alzheimer, Mitochondrial and Prionic disorders. We use an integrated experimental and computational approach to understand the molecular mechanisms underlying the conformational changes that cause the conversion of functional proteins into cytotoxic aggregates and their propagation in tissues.

Àrees:

  Transtorns del Sistema Nerviós Central   Mort neuronal 

Paraules clau:

Protein Folding, Protein Misfolding, Protein Aggregation, Conformational Disorders, Protein Design, Amyloid Fibrils, Prions, Transthyretin, Alzheimer, Bioinformatics

Publicacions:

1-Villar-Pique A. and Ventura S. Protein aggregation propensity is a crucial determinant of intracellular inclusions formation and quality control degradation BBA - Molecular Cell Research 1833(12):2714-24 (2013) 

2- Angarica, V.E., Ventura, S. and Sancho, J. Discovering putative prion sequences in complete proteomes using probabilistic representations of Q/N-rich domains. BMC Genomics 14:316 (2013) 

3- Sabate R., Rodríguez-Santiago L., Sodupe M., Saupe S.J. and Ventura S. Thioflavin-T Excimers Formation upon interaction with Amyloid Fibers. Chemical Communications 49(51):5745-7 (2013)

Pàgina Web del grup


 

IEC  SCB  INC-UAB  UAB

Institut d'Estudis Catalans. Carrer del Carme 47. 08001 Barcelona.
Telèfon +34 933 248 584. Fax +34 932 701 180. scb@iec.cat

- 2014 -



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