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principal investigator :
Salvador Ventura
salvador.ventura@uab.es
Department:
Proteómica Aplicada e Ingeniería de Proteínas
Center:
Institut de Biotecnologia i Biomedicina
Institution:
UAB (Universitat Autňnoma de Barcelona)
Members: 6
Research lines:
Our research interests are protein folding, misfolding and amyloid formation, with special focus on their role in conformational diseases such as Alzheimer, Mitochondrial and Prionic disorders. We use an integrated experimental and computational approach to understand the molecular mechanisms underlying the conformational changes that cause the conversion of functional proteins into cytotoxic aggregates and their propagation in tissues.
Areas:
Central Nervous System Disorders
Neuronal death
Keywords:
Protein Folding, Protein Misfolding, Protein Aggregation, Conformational Disorders, Protein Design, Amyloid Fibrils, Prions, Transthyretin, Alzheimer, Bioinformatics
Publications:
1-Villar-Pique A. and Ventura S.
Protein aggregation propensity is a crucial determinant of intracellular inclusions formation and quality control degradation
BBA - Molecular Cell Research 1833(12):2714-24 (2013)
2- Angarica, V.E., Ventura, S. and Sancho, J.
Discovering putative prion sequences in complete proteomes using probabilistic representations of Q/N-rich domains.
BMC Genomics 14:316 (2013)
3- Sabate R., Rodríguez-Santiago L., Sodupe M., Saupe S.J. and Ventura S.
Thioflavin-T Excimers Formation upon interaction with Amyloid Fibers.
Chemical Communications 49(51):5745-7 (2013)
Group Web site
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