phosphodiesterase 5, multiple sclerosis, experimental autoimmune encephalomyelitis, neuroprotection, remyelination, microglia/macrophage M2 phenotype, T regulatory cells, Alzheimer, histone acetylation
Pifarré P, Gutierrez-Mecinas M, Prado J, Usero L, Roura-Mir C, Giralt M, Hidalgo J, Garcia A. Phosphodiesterase 5 inhibition at disease onset prevents experimental autoimmune encephalomyelitis progression through immunoregulatory and neuroprotective actions. Exp. Neurol. 251:58-71, 2014
Pifarré P, Prado J, Baltrons MA, Giralt M, Gabarró, Feinstein DL, Hidalgo J, Garcia A. Sildenafil (Viagra) ameliorates clinical symptoms and neuropathology in a mouse model of multiple sclerosis. Acta Neuropathol. 121:499-508, 2011.
Pifarré P, Prado J, Giralt M, Molinero A, Hidalgo J, Garcia A. Cyclic GMP phosphodiesterase inhibition alters the glial inflammatory response, reduces oxidative stress and cell death and increases angiogenesis following focal brain injury. J. Neurochem 112: 807–817, 2010