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Neuroimmunology

principal investigator : Agustina García Agustina.Garcia@uab.cat Department: Mecanismes de resposta a estrès i malalties Center: Institut de Biotecnologia i de Biomedicina Institution: UAB (Universitat Autònoma de Barcelona) Members: 4 Research lines: Immunoregulatory and neuroprotective effects of PDE5 inhibitors in multiple sclerosis and Alzheimer’s disease models Areas:  Central Nervous System Disorders   Signalling   Neuronal death   Glial cells  Keywords: phosphodiesterase 5, multiple sclerosis, experimental autoimmune encephalomyelitis, neuroprotection, remyelination, microglia/macrophage M2 phenotype, T regulatory cells, Alzheimer, histone acetylation Publications: Pifarré P, Gutierrez-Mecinas M, Prado J, Usero L, Roura-Mir C, Giralt M, Hidalgo J, Garcia A. Phosphodiesterase 5 inhibition at disease onset prevents experimental autoimmune encephalomyelitis progression through immunoregulatory and neuroprotective actions. Exp. Neurol. 251:58-71, 2014  Pifarré P, Prado J, Baltrons MA, Giralt M, Gabarró, Feinstein DL, Hidalgo J, Garcia A. Sildenafil (Viagra) ameliorates clinical symptoms and neuropathology in a mouse model of multiple sclerosis. Acta Neuropathol. 121:499-508, 2011.  Pifarré P, Prado J, Giralt M, Molinero A, Hidalgo J, Garcia A. Cyclic GMP phosphodiesterase inhibition alters the glial inflammatory response, reduces oxidative stress and cell death and increases angiogenesis following focal brain injury. J. Neurochem 112: 807–817, 2010 Group Web site