Neuroprotection, Basal ganglia, Huntington's disease, Neurotrophic factors, Neurodegenerative disorders, Treatment, Neuronal dysfunction, Neuronal death, Synaptic plasticity
Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models.
Marco S, Giralt A, Petrovic MM, Pouladi MA, Martínez-Turrillas R, Martínez-Hernández J, Kaltenbach LS, Torres-Peraza J, Graham RK, Watanabe M, Luján R, Nakanishi N, Lipton SA, Lo DC, Hayden MR, Alberch J, Wesseling JF, Pérez-Otańo I.
Nat Med. 2013 Aug;19(8):1030-8.
Prostaglandin E2 EP1 Receptor Antagonist Improves Motor Deficits and Rescues Memory Decline in R6/1 Mouse Model of Huntington's Disease.
Anglada-Huguet M, Xifró X, Giralt A, Zamora-Moratalla A, Martín ED, Alberch J.
Mol Neurobiol. 2013 Nov 7
Conditional BDNF release under pathological conditions improves Huntington's disease pathology by delaying neuronal dysfunction.
Giralt A, Carretón O, Lao-Peregrin C, Martín ED, Alberch J.
Mol Neurodegener. 2011 Oct 10;6(1):71.