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Pathophysiology of neurodegenerative diseases

principal investigator : Jordi Alberch alberch@ub.edu Department: Biologia Cel·lular, Immunologia i Neurociències Center: Facultat de Medicina Institution: UB (Universitat de Barcelona), IDIBAPS Members: 5 Research lines: Mechanisms of neuroprotection by neurotrophic factors in Huntington's disease. Areas:  Central Nervous System Disorders   Signalling   Neuronal death  Keywords: Neuroprotection, Basal ganglia, Huntington's disease, Neurotrophic factors, Neurodegenerative disorders, Treatment, Neuronal dysfunction, Neuronal death, Synaptic plasticity Publications: Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models. Marco S, Giralt A, Petrovic MM, Pouladi MA, Martínez-Turrillas R, Martínez-Hernández J, Kaltenbach LS, Torres-Peraza J, Graham RK, Watanabe M, Luján R, Nakanishi N, Lipton SA, Lo DC, Hayden MR, Alberch J, Wesseling JF, Pérez-Otaño I. Nat Med. 2013 Aug;19(8):1030-8.  Prostaglandin E2 EP1 Receptor Antagonist Improves Motor Deficits and Rescues Memory Decline in R6/1 Mouse Model of Huntington's Disease. Anglada-Huguet M, Xifró X, Giralt A, Zamora-Moratalla A, Martín ED, Alberch J. Mol Neurobiol. 2013 Nov 7  Conditional BDNF release under pathological conditions improves Huntington's disease pathology by delaying neuronal dysfunction. Giralt A, Carretón O, Lao-Peregrin C, Martín ED, Alberch J. Mol Neurodegener. 2011 Oct 10;6(1):71.