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Proliferation and Differentiation of the Nervous System

principal investigator : Mariona Arbonés mariona.arbones@crg.es Department: Developmental Biology Center: Institut de Biologia Molecular de Barcelona Institution: CSIC Members: 5 Research lines: Our group is interested in the molecular mechanisms that control the number and variety of cells in the central nervous system using the mouse as an experimental model. The group's current projects include the study of the protein kinase DYRK1A in the development of the cerebral cortex and its implications for genetic disorders such as Down syndrome or autism. Areas:  Development   Neuronal death   Cognition  Keywords: Neural precursor, cell cycle, proliferation, apoptosis, cerebral cortex, retina, Down syndrome, autism spectrum disorders, DYRK kinases Publications: 1. Laguna A, Barallobre MJ, Marchena M, Mateus C, Ramírez E, Martínez-Cue C, Delabar JM, Castelo-Branco M, de la Villa P, Arbonés ML. Triplication of DYRK1A causes retinal structural and functional alterations in Down syndrome. Human Molecular Genetics 22, 2775-84 (2013).  2. Ferron SR, Pozo N, Laguna A, Aranda S, Porlan E, Moreno M, Fillat C, de la Luna S, Sánchez P, Arbonés ML*, Fariñas I*. Regulated segregation of kinase Dyrk1A during asymmetric neural stem cell division is critical for EGFR-mediated biased signaling. Cell Stem Cell 3, 367-79 (2010). *Joined corresponding authors.  3. Laguna A, Aranda S, Barallobre MJ, Barhoum R, Fernández E, Fotaki V, Delabar JM, De la Luna S, De la Villa P, Arbonés ML. The protein kinase DYRK1A regulates caspase-9 mediated apoptosis during retina development. Developmental Cell 15, 841-853 (2008). Group Web site