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Neurodegeneration and Synaptic Dysfunction in Huntington's disease

principal investigator : Silvia Ginés silviagines@ub.edu Department: Biologia Cel·lular, Inmunologia i Neurociències/Unitat Histologia Center: Facultat de Medicina (Campus Casanova) Institution: UB (Universitat de Barcelona), IDIBAPS Members: 5 Research lines: Molecular mechanisms involved in cognitive and motor deficits of Huntington's disease. Role of cortico-striatal and hippocampal circuits. In particular the group is interested in: -role of P75NTR receptor in striatal vulnerability and cognitive deficits in Huntington's disease - Role of kalirin in cognitive deficits in cortico-striatal-dependent and hippocampal circuits in Huntington's disease. Areas:  Signalling   Neuronal death   Cognition  Keywords: Neurodegenerative diseases. Huntington´s disease. Cognitive deficits. Synaptic deficits. Neurotrophic factors. Cdk5. Pharmacological therapies Publications: 1-Brito V, Puigdellívol M, Giralt A, del Toro D, Alberch J, Ginés S.Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: implication for neuroprotective therapies. Cell Death Dis. 2013;4:e595.  2-Giralt A, Puigdellívol M, Carretón O, Paoletti P, Valero J, Parra-Damas A, Saura CA, Alberch J, Ginés S.Long-term memory deficits in Huntington's disease are associated with reduced CBP histone acetylase activity. Hum Mol Genet. 2012 21(6):1203-16.  3-Paoletti P, Vila I, Rifé M, Lizcano JM, Alberch J, Ginés S.Dopaminergic and glutamatergic signaling crosstalk in Huntington's disease neurodegeneration: the role of p25/cyclin-dependent kinase 5. J Neurosci. 2008;28(40):10090-101. Group Web site