Laboratory of Molecular Neuropharmacology and Bioinformatics
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principal investigator :
Jesús Giraldo, Jordi Ortiz, Maria Josefa Sabrià, Carles Gil
jesus.giraldo@uab.es
Department:
Institut de Neurociencies
Center:
Facultat de Medicina
Institution:
UAB (Universitat Autònoma de Barcelona)
Members: 10
Research lines:
Mathematical modeling of GPCR function, Receptor heteromerization, Membrane microdomains
Areas:
Central Nervous System Disorders
Neurotransmission
Signalling
Keywords:
GPCR, glutamate, dopamine, histamine, cholesterol, raft, neuropathic pain, schizophrenia, cocaine, ethanol
Publications:
The asymmetric/symmetric activation of GPCR dimers as a possible mechanistic rationale for multiple signalling pathways. Rovira X, Pin JP, Giraldo J. Trends Pharmacol Sci. 2010 Jan;31(1):15-21.
Dopamine D1-histamine H3 receptor heteromers provide a selective link to MAPK signaling in GABAergic neurons of the direct striatal pathway. Moreno E, Hoffmann H, Gonzalez-Sepúlveda M, Navarro G, Casadó V, Cortés A, Mallol J, Vignes M, McCormick PJ, Canela EI, Lluís C, Moratalla R, Ferré S, Ortiz J, Franco R. J Biol Chem. 2011 Feb 18;286(7):5846-54.
Differential sensitivity to detergents of actin cytoskeleton from nerve endings. Cubí R, Matas LA, Pou M, Aguilera J, Gil C. Biochim Biophys Acta. 2013 Nov;1828(11):2385-93.
Group Web site
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