Laboratory of Molecular Neuropharmacology and Bioinformatics

principal investigator :

Jesús Giraldo, Jordi Ortiz, Maria Josefa Sabrià, Carles Gil
jesus.giraldo@uab.es

Department:

Institut de Neurociencies

Center:

Facultat de Medicina

Institution:

UAB (Universitat Autònoma de Barcelona)

Members: 10

Research lines:

Mathematical modeling of GPCR function, Receptor heteromerization, Membrane microdomains

Areas:

 Central Nervous System Disorders   Neurotransmission   Signalling 

Keywords:

GPCR, glutamate, dopamine, histamine, cholesterol, raft, neuropathic pain, schizophrenia, cocaine, ethanol

Publications:

The asymmetric/symmetric activation of GPCR dimers as a possible mechanistic rationale for multiple signalling pathways. Rovira X, Pin JP, Giraldo J. Trends Pharmacol Sci. 2010 Jan;31(1):15-21.

Dopamine D1-histamine H3 receptor heteromers provide a selective link to MAPK signaling in GABAergic neurons of the direct striatal pathway. Moreno E, Hoffmann H, Gonzalez-Sepúlveda M, Navarro G, Casadó V, Cortés A, Mallol J, Vignes M, McCormick PJ, Canela EI, Lluís C, Moratalla R, Ferré S, Ortiz J, Franco R. J Biol Chem. 2011 Feb 18;286(7):5846-54.

 Differential sensitivity to detergents of actin cytoskeleton from nerve endings. Cubí R, Matas LA, Pou M, Aguilera J, Gil C. Biochim Biophys Acta. 2013 Nov;1828(11):2385-93.

Group Web site


 

IEC  SCB  INC-UAB  UAB

Institut d'Estudis Catalans. Carrer del Carme 47. 08001 Barcelona.
Telèfon +34 933 248 584. Fax +34 932 701 180. scb@iec.cat

- 2014 -



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El Mapa de la recerca en neurociències a Catalunya de Josep Saura Martí i Josefa Sabrià Pau està subjecta a una llicència de Reconeixement-NoComercial 3.0 No adaptada de Creative Commons