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Neurodeath Laboratory

principal investigator : Jose Rodriguez Alvarez jose.rodriguez@uab.es Department: Bioquímica i Biología Molecular Center: Institut de Neurociències Institution: UAB (Universitat Autònoma de Barcelona) Members: 6 Research lines: 1. Synaptic activity and extracellular modulation of neuronal apoptosis Areas:  Signalling   Neuronal death  Keywords: neurodegeneration, apoptosis, glutamate, synapse, alzheimer, death receptors, signal transduction, gene expression Publications: Fadó, R., Moubarak, R., Miñano-Molina, A.J., Barneda-Zahonero, B., Valero, J., Saura, C.A., Morán, J., Comella, J.X. and J. Rodríguez-Alvarez. X-linked inhibitor of apoptosis protein negatively regulates neurite outgrowth through interaction with cRAF and Trk. Sci Reports. 3:2397 (2013)  Barneda-Zahonero, B., Servitja, J.M., Badiola, N., Miñano-Molina, A.J., Fadó, R., Saura, C.A. and J. Rodriguez-Alvarez. Nurr1 is required for NMDA receptor-mediated neuronal survival. J. Biol. Chem. 287:11351-11362 (2012)  Miñano-Molina, A.J., España, J., Martin, E. Barneda-Zahonero, B., Fadó, R., Solé, M., Trullás, R., Saura, C.A. and J. Rodríguez-Alvarez. Soluble oligomers of amyloid-beta peptide disrupt membrane trafficking of AMPA receptors contributing to early synapse dysfunction. J Biol. Chem. 286:27311-27321 (2011) Group Web site