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Molecular Physiology

principal investigator : Antonio Felipe afelipe@ub.edu Department: Bioquímica i Biologia Molecular Center: Institut de Biomedicina Institution: Universitat de Barcelona (UB) Members: 10 Research lines: Ion channels Areas:  Central Nervous System Disorders   Neurotransmission   Glial cells  Keywords: ion channels, channelosome, traffic, association, functional complex Publications: 1. A non-canonical di-acidic signal at the C-terminus of Kv1.3 determines anterograde trafficking and surface expression. Martínez-Mármol R, Pérez-Verdaguer M, Roig SR, Vallejo-Gracia A, Gotsi P, Serrano-Albarrás A, Bahamonde MI, Ferrer-Montiel A, Fernández-Ballester G, Comes N, Felipe A. J Cell Sci. 2013 Dec 15;126(Pt 24):5681-91   2. KCNE4 suppresses Kv1.3 currents by modulating trafficking, surface expression and channel gating. Solé L, Roura-Ferrer M, Pérez-Verdaguer M, Oliveras A, Calvo M, Fernández-Fernández JM, Felipe A. J Cell Sci. 2009 Oct 15;122(Pt 20):3738-48.   3. Kv1.5 association modifies Kv1.3 traffic and membrane localization. Vicente R, Villalonga N, Calvo M, Escalada A, Solsona C, Soler C, Tamkun MM, Felipe A. J Biol Chem. 2008 Mar 28;283(13):8756-64. Notes: Group Web site