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Immunopathogenesis of Autoimmune Encephalitis and Neurological Paraneoplasic Diseases

principal investigator : Josep Dalmau jdalmau@clinic.ub.es Department: Neurociències clíniques i experimentals Center: Centre d’Investigació Biomèdica CELLEX Institution: ICREA - Institut d’Investigació Biomèdiques August Pi i Sunyer (IDIBAPS) Members: 15 Research lines: - Autoimmune mechanisms in neurological paraneoplasic diseases. - Autoimmune synaptic encephalitis and other autoimmune diseases of the central nervous system. - Development of new biomarkers and therapies for the treatment of autoimmune diseases of the central nervous system. Areas:  Central Nervous System Disorders   Neurotransmission   Glial cells  Keywords: autoimmunity, neuroscience, neurology, pathophysiology, inflammation, encephalitis, paraneoplastic, biomarkers Publications: Petit-Pedrol M, Armangue T, Peng X, Bataller L, Cellucci T, Davis R, McCracken L, Martinez-Hernandez E, Mason WP, Kruer MC, Ritacco DG, Grisold W, Meaney BF, Alcalá C, Sillevis-Smitt P, Titulaer MJ, Balice-Gordon R, Graus F, Dalmau J. Encephalitis with refractory seizures, status epilepticus, and antibodies to the GABAA receptor: a case series characterization of the antigen, and analysis of the effects of antibodies. Lancet Neurol, 2014, 13: 276-286.  Gresa-Arribas N, Titulaer MJ, Torrents A, Aguilar E, McCracken L, Leypoldt F, Gleichman AJ, Balice-Gordon R, Rosenfeld MR, Lynch D, Graus F, Dalmau J. Antibody titres at diagnosis and during follow-up of anti-NMDA receptor encephalitis: a retrospective study. Lancet Neurol, 2014, 13: 167-177.  Grau-Rivera O, Sánchez-Valle R, Saiz A, Molinuevo JL, Bernabé R, Munteis E, Pujadas F, Salvador A, Saura J, Ugarte A, Titulaer M, Dalmau J, Graus F. Determination of neuronal antibodies in suspected and definite Creutzfeldt-Jakob disease. JAMA Neurol 2014;71:74-78. Group Web site