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principal investigator :
Bernardo Castellano - Berta González
bernardo.castellano@uab.cat
Department:
Biologia Cel·lular, Fisiologia i Immunologia/Unitat de Histologia
Institut de Neurociencies
Center:
Facultat de Medicina
Institution:
UAB (Universitat Autňnoma de Barcelona)
Members: 6
Research lines:
Signaling and molecular mechanisms involved in the modulation of the activation, proliferation and death of glial cells in experimental models of innate and acquired immunity. Involvement of glial cells in the regulation of associated immune and inflammatory responses.
Areas:
Central Nervous System Disorders
Signalling
Development
Neuronal death
Glial cells
Keywords:
microglia, astrocits, lesions, neurodegeneració, regeneració, citoquines, transgenics, IL-6, IL-10, neuroinflamació
Publications:
B. Almolda, B. González and B Castellano.
Antigen presentation in EAE: role of microglia, macrophages and dendritic cells.
Frontiers in Biosciences, 16:1157-71, Review (2011)
B. Almolda, M. Costa, M. Montoya B. González and B Castellano.
Increase in Th17 and T-reg lymphocytes and decrease of IL22 correlate with the recovery phase of acute EAE in rat.
PLoS One, 2011;6(11):e27473. Epub 2011 Nov 7 (2011)
P. Gonzalez, H. Peluffo, L. Acarin, A. Villaverde, B. Gonzalez and B Castellano.
Interleukin-10 overexpression does not synergize with the neuroprotective action of RGD-containing vectors after postnatal brain excitotoxicity but modulates the main inflammatory cell responses.
J Neurosci Res. 90:143-59 (2012)
Group Web site
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