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Gene Therapy Strategies for Diseases Affecting the Central Nervous System

principal investigator : Miguel Chillón Rodríguez miguel.chillon@uab.cat Department: Bioquímica i Biologia Molecular Center: CBATEG Institution: ICREA (Institució Catalana de Recerca i Estudis Avançats), UAB (Universitat Autònoma de Barcelona) Members: 8 Research lines: 1) Generation and development of more selective and less immunogenic viral vectors. 2) Molecular mechanisms involved in memory formation: Study of altered signaling pathways in CNS in aging and in Alzheimer's Disease. 3) Gene Therapy Strategies for Esclerosis Multiple, an autoimmune disease affecting the nervous system. Areas:  Central Nervous System Disorders   Signalling   Cognition  Keywords: Gene Therapy; Viral vectors; CNS; PNS; Multiple Sclerosis; Alzheimer Disease; Aging; Th17 pathway; IR/IGF1R pathway; neurodegeneration Publications: Efficient amplification of chimeric adenovirus 5/40S vectors carrying the short fiber protein of Ad40 in suspension cell cultures. Miralles M, Segura MM, Puig M, Bosch A, Chillon M. PLoS One. 2012;7(7):e42073. doi: 10.1371/journal.pone.0042073. Epub 2012 Jul 31.   Chromatography purification of canine adenoviral vectors. Segura MM, Puig M, Monfar M, Chillón M. Hum Gene Ther Methods. 2012 Jun;23(3):182-97. doi: 10.1089/hgtb.2012.058. Epub 2012 Jul 16. Short-fiber protein of ad40 confers enteric tropism and protection against acidic gastrointestinal conditions.  Rodríguez E, Romero C, Río A, Miralles M, Raventós A, Planells L, Burgueño JF, Hamada H, Perales JC, Bosch A, Gassull MA, Fernández E, Chillon M. Hum Gene Ther Methods. 2013 Aug;24(4):195-204. doi: 10.1089/hgtb.2012.096. Epub 2013 Jun 27. Group Web site