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Neuropharmacology

principal investigator : M Victoria Clos - Albert Badia victoria.clos@uab.cat Department: Farmacologia, Terapèutica i Toxicologia Center: Fac Medicina, Fac Veterinària Institution: UAB (Universitat Autònoma de Barcelona) Members: 3 Research lines: Neuropharmacology of neurodegenerative disorders: - The cholinergic system in the development of Alzheimer's disease: role of the different AChE variants and anticholinesterase drugs in neurogenesis and neurodegeneration. - Multifunctional pharmacological evaluation of new drugs. Areas:  Central Nervous System Disorders   Neurotransmission   Neuronal death   Cognition   Farmacocinètica (pas a través de membranes, ...)   Keywords: Huprine X  Huperzine A  Acetylcholinesterase inhibitors  Cognitive improvement  Learning and memory  Protein kinase C   Mitogen-activated protein kinase   -Secretases (TACE/ADAM17)  Glycogen synthase kinase-3   3xTg-AD mice Publications: M. Pera, S. Román, M. Ratia, P. Camps, D. Muñoz-Torrero, L. Colombo, C. Manzoni, M. Salmona, A. Badia,Clos MV (2006) Acetylcholinesterase triggers the aggregation of PrP 106-126. Biochem Biophys Res Commun; 346: 89-94.  Monika M. Hedberga, M. Victoria Clos, Miriam Ratia, Daniel Gonzalez, Christina Unger Lithner, Pelayo Camps, Diego Muñoz-Torrero, Albert Badia, Lydia Giménez-Llort and Agneta Nordberg (2010)Effect of huprine X on A-beta, synaptophysin and alfa-7 neuronal nicotinic acetylcholine receptors in the brain of 3xTg-AD and APPswe transgenic mice. Neurodegener Dis. 2010;7(6):379-88.  Muñoz-Torrero D, Pera M, Relat J, Ratia M, Galdeano C, Viayna E, Sola I, Formosa X, Camps P, Badia A, Clos MV (2012) Expanding the Multipotent Profile of Huprine-Tacrine Heterodimers as Disease-Modifying Anti-Alzheimer Agents. Neurodegener Dis.10(1-4):96-9