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Behavioral Neuroscience

principal investigator : Lydia Giménez-Llort lidia.gimenez@uab.cat Department: 1) Institut de Neurociències 2) Departament de Psiquiatria i Medicina Legal, Unitat de Psicologia Mèdica Center: 1, 2) Facultat de Medicina Institution: UAB (Universitat Autònoma de Barcelona) Members: 2 Research lines: 1) Biological bases of cognitive stimulation in neurodegenerative diseases: studies in 3xTg-AD Alzheimer's disease mouse model. 2) Neuroimmunoendocrine modulation, risk factors and preventive and therapeutic strategies in hypoxia / ischemia, neurodegenerative diseases and aging. 3) Phenotypic characterization of neurological and psychiatric diseases animal models Areas:  Central Nervous System Disorders   Neurotransmission   Cognition  Keywords: Behavior, Phenotype, Mice, Mutant mice, Alzheimer's disease, prevention, biological age, aging Publications: Localization of cholesterol, amyloid and glia in Alzheimer's disease transgenic mouse brain tissue using time-of-flight secondary ion mass spectrometry (ToF-SIMS) and immunofluorescence imaging. Solé-Domènech S, Sjövall P, Vukojeviand#263; V, Fernando R, Codita A, Salve S, Bogdanoviand#263; N, Mohammed AH, Hammarström P, Nilsson KP, LaFerla FM, Jacob S, Berggren PO, Giménez-Llort L, Schalling M, Terenius L, Johansson B. Acta Neuropathol. 2013 Jan;125(1):145-57.  Peripheral immune system and neuroimmune communication impairment in a mouse model of Alzheimer's disease. Giménez-Llort L, Maté I, Manassra R, Vida C, De la Fuente M. Ann N Y Acad Sci. 2012 Jul;1262:74-84. doi: 10.1111/j.1749-6632.2012.06639.x. Review.  Early intervention in the 3xTg-AD mice with an amyloid and#946;-antibody fragment ameliorates first hallmarks of Alzheimer disease. Giménez-Llort L, Rivera-Hernández G, Marin-Argany M, Sánchez-Quesada JL, Villegas S. MAbs. 2013 Sep-Oct;5(5):665-77. doi: 10.4161/mabs.25424. Epub 2013 Jun 20. Group Web site