The group consists of clinical neurologists with training in basic research and basic researchers who are integrated into the clinical activities to achieve a constant feed-back between them. Our research develops primarily from human samples and clinical observations. This has led to the discovery of potential biomarkers for diagnosis and prognosis in inflammatory neuropathies and myasthenia gravis, a description of the regenerative potential of pericytes, diagnostic tests and biomarkers in muscular dystrophies and genetic studies in ALS.
Autoimmune neurology, Adaptative immunity CIDP, Innate immunity inflammatory myopathies,Translational research, Muscular dystrophy, Biomarkers neuromuscular diseases, Clinical trials.
Antibodies to contactin-1 in chronic inflammatory demyelinating polyneuropathy.
Querol L, Nogales-Gadea G, Rojas-Garcia R, Martinez-Hernandez E, Diaz-Manera J, Suárez-Calvet X, Navas M, Araque J, Gallardo E, Illa I. Ann Neurol. 2013 Mar;73(3):370-80
25(OH)(2)-Vitamin D3 increases dysferlin expression in vitro and in a human clinical trial. Luna ND, Díaz-Manera J, Paradas C, Iturriaga C, Rojas-García R, Araque J, Genebriera M, Gich I, Illa I, Gallardo E. Mol Ther. 2012 Oct;20(10):1988-97
Long-lasting treatment effect of rituximab in MuSK myasthenia. Díaz-Manera J, Martínez-Hernández E, Querol L, Klooster R, Rojas-García R, Suárez-Calvet X, Muńoz-Blanco JL, Mazia C, Straasheijm KR, Gallardo E, Juárez C, Verschuuren JJ, Illa I. Neurology. 2012 Jan 17;78(3):189-93
