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Molecular Physiology of Synapses

principal investigator : Àlex Bayés abayesp@santpau.cat Department: Center: Institution: Institut d´Investigació Biomèdica Sant Pau Members: 4 Research lines: Molecular analysis and cell synapses in the central nervous system of vertebrates. Study of the molecular and cellular dysfunctions involved in intellectual disability and autism Development and analysis of animal models of mental and behavioral disorders. Development of new biochemical approaches to the study of synapses in the central nervous system. Areas:  Central Nervous System Disorders   Neurotransmission   Signalling   Development   Cognition  Keywords: Synapse, Proteomics, Intelectual Disability, Bioinformtics, Biochemistry, Systems Biology, Mass Spectrometry Publications: Characterization of the proteome, diseases and evolution of the human postsynaptic density. Bayés A, van de Lagemaat LN, Collins MO, Croning MD, Whittle IR, Choudhary JS, Grant SG. Nat Neurosci. 2011 Jan;14(1):19-21.  Neuroproteomics: understanding the molecular organization and complexity of the brain. Bayés A, Grant SG. Nat Rev Neurosci. 2009 Sep;10(9):635-46. Evolutionary expansion and anatomical specialization of synapse proteome complexity. Emes RD, Pocklington AJ, Anderson CN, Bayes A, Collins MO, Vickers CA, Croning MD, Malik BR, Choudhary JS, Armstrong JD, Grant SG. Nat Neurosci. 2008 Jul;11(7):799-806. Group Web site