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Pathophysiology and Toxicology of Sensory and Motor Systems (FIPTOXSIM)

principal investigator : Jordi Llorens jllorens@ub.edu Department: Departament de Ciències Fisiològiques II Center: Campus de Bellvitge Institution: Universitat de Barcelona (UB) Members: 3 Research lines: 1. – Sensory Pathophysiology, mainly the study of the mechanisms involved in the toxic origin of vestibular injury and repair. 2. - Neurofilamentous axonopathies of neurotoxic origin. Implications for amyotrophic lateral sclerosis. 3. - Neurotoxicity of nitriles. Role of neurotoxicity of nitriles from natural food sources in neurological diseases. Areas:  Central Nervous System Disorders   Neuronal death  Keywords: Neurotoxicology. Sensory systems. Vestibular hair cells. Ototoxicity. Neurofilamentous axonopathies. Neuromuscular junction. Amyotrophic lateral sclerosis. Nitriles. Konzo. Tropical ataxic neuropathy. Publications: Soler-Martín C., Boadas-Vaello P., Verdú E., Garcia N., Llorens J. Chronic proximal axonopathy associates with enduring neurofilament depletion in the neuromuscular junction and behavioral deficits in the rat. Journal of Neuropathology and Experimental Neurology 73: 568-579 (2014)   Rúa F., Buffard M., Sedó-Cabezón L., Hernández-Mir G, de la Torre A, Saldaña-Ruíz S, Chabbert C, Bayona J.M., Messeguer A., Llorens J. Vestibulotoxic properties of potential metabolites of allylnitrile. Toxicological Sciences 135: 182-192 (2013)   Saldaña-Ruíz S., Boadas-Vaello P., Sedó-Cabezón L., Llorens J. Reduced systemic toxicity and preserved vestibular toxicity following co-treatment with nitriles and CYP2E1 inhibitors: a mouse model for hair cell loss. Journal of the Association for Research in Otolaryngology 14: 661-671 (2013) Notes: Group Web site