Systems Neuropharmacology
|
principal investigator :
Francesc Artigas
francesc.artigas@iibb.csic.es
Department:
Departament de Neuroquímica i Neurofarmacología
Center:
Institut d'Investigacions Biomèdiques de Barcelona (CSIC-IDIBAPS)
Institution:
CSIC, IDIBAPS
Members: 18
Research lines:
• Neurobiological basis and treatment of severe psychiatric disorders: neurotransmitters, receptors and brain circuits involved.
• Mechanism of action of antidepressants and antipsychotic drugs: circuits involved.
• A study of brain circuits involved in the action of NMDA antagonists as models of schizophrenia.
• New therapeutic strategies in neuropsychiatric disorders (deep brain stimulation, RNA interference, ketamine).
• Study of transgenic models of schizophrenia.
• Neurochemistry and neuropharmacology of cerebral neurotransmission systems.
Areas:
Central Nervous System Disorders
Neurotransmission
Cognition
Keywords:
Affective disorders, Psychotic disorders, Mood control, Cognition, Monoamines in mammalian brain, Antidepressant strategies, Neurobiological basis and treatment, Neurochemistry, Neuropharmacology
Publications:
Bortolozzi A, Castañé A, Semakova J, Santana N, Alvarado G, Cortés R, Ferrés-Coy A, Fernández G, Carmona MC, Toth M, Perales JC, Montefeltro A, Artigas F (2012) Selective siRNA-mediated suppression of 5HT(1A) autoreceptors evokes strong antidepressant-like effects. Mol Psychiatr 17:612-23 (Highlighted in Nature Reviews Neurology)
Kargieman L, Santana N, Mengod G, Celada P, Artigas F (2007) Antipsychotic drugs reverse the disruption in prefrontal cortex function produced by NMDA receptor blockade with phencyclidine. Proc Natl Acad Sci USA 104:14843-14848
Artigas F, Romero L, de Montigny C, Blier P (1996) Acceleration of the effect of selected antidepressant drugs in major depression by 5-HT1A antagonists. Trends Neurosci 19:378-383
Group Web site
|
|
|
