Neuronal viability
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principal investigator :
Francesc X. Soriano
f.x.soriano@ub.edu
Department:
Biologia Cel•lular
Center:
Facultat de Biologia
Institution:
Universitat de Barcelona (UB)
Members: 2
Research lines:
Mitochondrial dynamics and neuronal death.
Mitochondria are dynamic organelles which constantly change their shape and location. The balance between fusion and fission processes is important for mitochondrial function, which is not limited to energy production but also anabolic and catabolic processes involved in the homeostasis of intracellular Ca2+ and the regulation of cell death. We are interested in studying how to regulate mitochondrial dynamics in neurodegenerative conditions and their impact on neuronal death.
Neuronal metabolism and neuroprotection.
During the past decade it has been established that cell signaling and cell metabolism are not independent entities. Metabolism and several signaling cascades are self-regulated by modifying cellular processes such as resistance to various stressor stimuli. Our research studies the metabolic changes induced by synaptic activity and its role in neuroprotection.
Areas:
Central Nervous System Disorders
Signalling
Neuronal death
Keywords:
mitochondrial dynamics, excitotoxicity, transcriptional regulation, synaptic activity, metabolism
Publications:
- Martorell-Riera A, Segarra-Mondejar M, Muñoz JP, Ginet V, Olloquequi J, Pérez-Clausell J, Palacín M, Reina M, Puyal J, Zorzano A, Soriano FX. Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death. EMBO J. 2014 Aug 21. pii: e201488327. [Epub ahead of print]
- Soriano FX, Léveillé F, Papadia S, Bell KF, Puddifoot C, Hardingham GE. Neuronal activity controls the antagonistic balance between PGC-1α and SMRT in regulating antioxidant defences. Antioxid Redox Signal. 2011 Apr 15; 14(8):1425-36
- Papadia S, Soriano FX*, Léveillé F, Martel MA, Dakin KA, Hansen HH, Kaindl A, Sifringer M, Fowler J, Stefovska V, McKenzie G, Craigon M, Corriveau R, Ghazal P, Horsburgh K, Yankner BA, Wyllie DJ, Ikonomidou C, Hardingham GE. Synaptic NMDA receptor activity boosts intrinsic antioxidant defences Nat. Neurosci. 2008 Apr; 11(4):476-87
* co-primer autor.
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