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Metabolic Engineering and Diabetes Therapy

principal investigator : Joan J. Guinovart - Jordi Duran guinovart@irbbarcelona.org - jordi.duran@irbbarcelona.org Department: Medicina Molecular Center: Institution: IRB Barcelona Members: 6 Research lines: Physiological and pathological roles of brain glycogen. Areas:  Central Nervous System Disorders   Neuronal death   Metabolisme del sistema nerviós  Keywords: Publications: Glycogen accumulation underlies neurodegeneration and autophagy impairment in Lafora disease. Duran J, Gruart A, García-Rocha M, Delgado-García JM, Guinovart JJ. Hum Mol Genet. 2014 Jun 15;23(12):3147-56. doi: 10.1093/hmg/ddu024. Epub 2014 Jan 22. Impairment in long-term memory formation and learning-dependent synaptic plasticity in mice lacking glycogen synthase in the brain. Duran J, Saez I, Gruart A, Guinovart JJ, Delgado-García JM.J Cereb Blood Flow Metab. 2013 Apr;33(4):550-6. doi: 10.1038/jcbfm.2012.200. Epub 2013 Jan 2. Deleterious effects of neuronal accumulation of glycogen in flies and mice. Duran J, Tevy MF, Garcia-Rocha M, Calbó J, Milán M, Guinovart JJ.EMBO Mol Med. 2012 Aug;4(8):719-29. doi: 10.1002/emmm.201200241. Epub 2012 May 2. Group Web site