Clinical Research Program on Alzheimer's Disease
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principal investigator :
José Luis Molinuevo
jlmolinuevo@fpmaragall.org
Department:
Center:
Fundació Barcelonabeta Brain Research Center
Institution:
Fundació Pasqual Maragall
Members: 4
Research lines:
Our group is engaged in research on Alzheimer's disease (AD), healthy aging and clinical neuroscience and cognitive perspective. The Alzheimer's Project and Family (ALFA) is a longitudinal cohort of children of patients with AD, 45 to 76 years old, to explore the preclinical stage of the disease with the aim of identifying new risk factors and biomarkers. The project began in April 2013 and so far more than 2,500 cognitively healthy subjects were characterized in detail, including a neuropsychological assessment, determination of the clinical risk factors and lifestyle, APOE genotype as well as the underlying structural and associated functional alterations measured by MRI in a subgroup. This study will improve our understanding of the processes involved before the onset of AD to develop interventions aimed at preventing or delaying the disease.
Areas:
Central Nervous System Disorders
Neuronal death
Cognition
Keywords:
APOE, Biological Marker, CNS, Cognition, Longitudinal Study, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Normal Aging, Prevention, Risk Factor.
Publications:
1.Molinuevo JL, Gispert JD, Dubois B, Heneka M, Lleo A, Engelborghs S, Pujol J, de Souza LC, Alcolea D, Jessen F, Sarazin M, Lamari F, Balasa M, Antonell A, Rami L.. “The AD-CSF-Index Discriminates Alzheimer's Disease Patients from Healthy Controls: A Validation Study.”. Journal of Alzheimer’s 2013 Jan 1;36(1):67-77.
2.Arenaza-Urquijo EM, Molinuevo JL, Sala-Llonch R, Solé-Padullés C, Balasa M, Bosch B, Olives J, Antonell A, Lladó A, Sánchez-Valle R, Rami L, Bartrés-Faz D. Cognitive Reserve Proxies Relate to Gray Matter Loss in Cognitively Healthy Elderly with Abnormal Cerebrospinal Fluid Amyloid-β Levels. J Alzheimers Dis. 2013;35(4):715-26
3.Molinuevo JL, Ripolles P, Simó M, Lladó A, Olives J, Balasa M, Antonell A, Rodriguez-Fornells A, Rami L. White matter changes in preclinical Alzheimer'sdisease: a magnetic resonance imaging-diffusion tensor imaging study on cognitively normal older people with positive amyloid β protein 42 levels. Neurobiol Aging. 2014 Jun 6. pii: S0197-4580(14)00393-5.
Group Web site
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