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Movement Disorders Unit

principal investigator : Eduard Tolosa etolosa@ub.edu Department: Neurodegenerative diseases: Clinical and experimental research Center: CELLEX Institution: Hospital Clínic, IDIBAPS Members: 10 Research lines: 1) Genetic analyses, biological markers and experimental therapies in Parkinson’s disease and other movement disorders. Genetic and expression studies in parkinsonisms. 2) Studies in in vivo and in vitro experimental models of the physiopathological mechanisms involved in Parkinson’s disease and other movement disorders. 3) Study of neurogenesis in the subventricular zone, olfactory bulb and striate nucleus in experimental models of Parkinson’s disease and tardive dyskinesia. Areas:  Central Nervous System Disorders   Neuronal death   neural epigenomics  Keywords: biomarkers, Parkinson's disease, epigenetics, iPSC-derived stem cells, LRRK2, miRNAs, PSP Publications: Compta Y, Martí MJ, Ibarretxe-Bilbao N, Junqué C, Valldeoriola F, Muñoz E, Ezquerra M, Ríos J, Tolosa E.Cerebrospinal tau, phospho-tau, and beta-amyloid and neuropsychological functions in Parkinson's disease.Mov Disord. 2009 Nov 15;24(15):2203-10.   Sánchez-Danés A, Richaud-Patin Y, Carballo-Carbajal I, Jiménez-Delgado S, Caig C, Mora S, Di Guglielmo C, Ezquerra M, Patel B, Giralt A, Canals JM, Memo M, Alberch J, López-Barneo J, Vila M, Cuervo AM, Tolosa E, Consiglio A, Raya A.Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease.EMBO Mol Med. 2012 May;4(5):380-95.  Botta-Orfila T, Tolosa E, Gelpi E, Sànchez-Pla A, Martí MJ, Valldeoriola F, Fernández M, Carmona F, Ezquerra M. Microarray expression analysis in idiopathic and LRRK2-associated Parkinson's disease.Neurobiol Dis. 2012 Jan;45(1):462-8. doi: 10.1016/j.nbd.2011.08.033. Group Web site