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Cell Signaling and Apoptosis

principal investigator : Joan X. Comella joan.comella@vhir.org Department: VHIR Center: VHIR Institution: Vall d’Hebron Institut de Recerca (VHIR) Members: 7 Research lines: Death Receptor antagonists in neuronal physiology Areas:  Signalling   Neuronal death   Glial cells  Keywords: Apoptosis, Alzheimer, neuroinflammation, death receptors, TNF, Fas, FAIM, Lifeguard, FLIP Publications: FAIM-L Is an IAP-Binding Protein That Inhibits XIAP Ubiquitinylation and Protects from Fas-Induced Apoptosis. Moubarak RS, Planells-Ferrer L, Urresti J, Reix S, Segura MF, Carriba P, Marqués-Fernàndez F, Sole C, Llecha-Cano N, Lopez-Soriano J, Sanchis D, Yuste VJ, Comella JX. J Neurosci. 2013 Dec 4;33(49):19262-75.  TNFa induces survival through the FLIP-L-dependent activation of the MAPK/ERK pathway. Marques-Fernandez F, Planells-Ferrer L, Gozzelino R, Galenkamp KM, Reix S, Llecha-Cano N, Lopez-Soriano J, Yuste VJ, Moubarak RS, Comella JX. Cell Death Dis. 2013 Feb 14;4:e493.  The death receptor antagonist FLIP-L interacts with Trk and is necessary for neurite outgrowth induced by neurotrophins. Moubarak RS, Solé C, Pascual M, Gutierrez H, Llovera M, Pérez-García MJ, Gozzelino R, Segura MF, Iglesias-Guimarais V, Reix S, Soler RM, Davies AM, Soriano E, Yuste VJ, Comella JX. J Neurosci. 2010 Apr 28;30(17):6094-105. Notes: Group Web site