Cell Signaling and Apoptosis

principal investigator :

Joan X. Comella
joan.comella@vhir.org

Department:

VHIR

Center:

VHIR

Institution:

Vall d’Hebron Institut de Recerca (VHIR)

Members: 7

Research lines:

Death Receptor antagonists in neuronal physiology

Areas:

 Signalling   Neuronal death   Glial cells 

Keywords:

Apoptosis, Alzheimer, neuroinflammation, death receptors, TNF, Fas, FAIM, Lifeguard, FLIP

Publications:

FAIM-L Is an IAP-Binding Protein That Inhibits XIAP Ubiquitinylation and Protects from Fas-Induced Apoptosis. Moubarak RS, Planells-Ferrer L, Urresti J, Reix S, Segura MF, Carriba P, Marqués-Fernàndez F, Sole C, Llecha-Cano N, Lopez-Soriano J, Sanchis D, Yuste VJ, Comella JX. J Neurosci. 2013 Dec 4;33(49):19262-75. 

TNFa induces survival through the FLIP-L-dependent activation of the MAPK/ERK pathway. Marques-Fernandez F, Planells-Ferrer L, Gozzelino R, Galenkamp KM, Reix S, Llecha-Cano N, Lopez-Soriano J, Yuste VJ, Moubarak RS, Comella JX. Cell Death Dis. 2013 Feb 14;4:e493. 

The death receptor antagonist FLIP-L interacts with Trk and is necessary for neurite outgrowth induced by neurotrophins. Moubarak RS, Solé C, Pascual M, Gutierrez H, Llovera M, Pérez-García MJ, Gozzelino R, Segura MF, Iglesias-Guimarais V, Reix S, Soler RM, Davies AM, Soriano E, Yuste VJ, Comella JX. J Neurosci. 2010 Apr 28;30(17):6094-105.

Notes:

Group Web site


 

IEC  SCB  INC-UAB  UAB

Institut d'Estudis Catalans. Carrer del Carme 47. 08001 Barcelona.
Telèfon +34 933 248 584. Fax +34 932 701 180. scb@iec.cat

- 2014 -



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