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Neurolipid Group

principal investigator : Núria Casals ncasals@csc.uic.es Department: Ciències Bàsiques Center: Facultat de Medicina i Ciències de la Salut Institution: Universitat Internacional de Catalunya (UIC) Members: 8 Research lines: Implications of neuronal lipid metabolism in obesity, cognition and regeneration of the peripheral nervous system Areas:  Signalling   Neuronal death   Cognition   Control hipotalàmic de la ingesta i del pes corporal  Keywords: Carnitine palmitoyl tranferase, ceramide, hypothalamus, ghrelin, fatty acid oxidation, AMPA receptors, lipid rafts, stem cells, purinergic signalling, Schwann cells. Publications: "Hypothalamic ceramide levels regulated by CPT1C mediate the orexigenic effect of ghrelin". Ramírez S, Martins L, Jacas J, Carrasco P, Pozo M, Clotet J, Serra D, Hegardt FG, Diéguez C, López M, Casals N. Diabetes. 62:2329-37. 2013  Carrasco P, Sahun I, McDonald J, Ramirez S, Jacas J, Gratacós E, Sierra AY, Serra, D, Herrero L, Acker-Palmer A, Hegardt FG, Dierssen M, Casals N. "Ceramide levels regulated by carnitine palmitoyl transferase 1C control dendritic spine maturation and cognition". Journal of Biological Chemistry, 287, 21224-21232 (2012)  Su Gao, Guangjing Zhu, Xuefei Gao, Donghai Wu, Patricia Carrasco, Nuria Casals, Fausto G. Hegard, Timothy H. Moran and Gary D. Lopaschuk "Important Roles for Brain-specific Carnitine Palmitoyltransferase and Ceramide Metabolism in Leptin Hypothalamic Control of Feeding2 Proc Natl Acad Sci U S A. 108(23):9691-6 (2011) Group Web site