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Cell Death, Senescence and Survival

principal investigator : Victor J. Yuste Victor.Yuste@uab.es Department: Dept. Bioquímica i Biologia Molecular (Unitat de Medicina) i Institut de Neurociències Center: Facultat de Medicina Institution: UAB (Universitat Autònoma de Barcelona) Members: 7 Research lines: Analysis of the alteration of the activation of the endonuclease ICAD / CAD system in cell apoptosis and relevance in human pathology. Areas:  Signalling   Neuronal death   Glial cells  Keywords: Apoptosis/drug effects, caspases, DNA Fragmentation, Deoxyribonucleases/metabolism, DFF40/CAD, apoptotic nuclear morphology, DNA Breaks/Single-Stranded/Double-Stranded. Publications: 1: Iglesias-Guimarais V, Gil-Guiñon E, Sánchez-Osuna M, Casanelles E, García-Belinchón M, Comella JX, Yuste VJ. Chromatin collapse during caspase-dependent apoptotic cell death requires DNA fragmentation factor, 40-kDa subunit-/caspase-activated deoxyribonuclease-mediated 3'-OH single-strand DNA breaks. J Biol Chem. 2013 Mar 29;288(13):9200-15.  2: Casanelles E, Gozzelino R, Marqués-Fernández F, Iglesias-Guimarais V, Garcia-Belinchón M, Sánchez-Osuna M, Solé C, Moubarak RS, Comella JX, Yuste VJ. NF-and#954;B activation fails to protect cells to TNFand#945;-induced apoptosis in the absence of Bcl-xL, but not Mcl-1, Bcl-2 or Bcl-w. Biochim Biophys Acta. 2013 May;1833(5):1085-95.  3: Iglesias-Guimarais V, Gil-Guiñon E, Gabernet G, García-Belinchón M, Sánchez-Osuna M, Casanelles E, Comella JX, Yuste VJ. Apoptotic DNA degradation into oligonucleosomal fragments, but not apoptotic nuclear morphology, relies on a cytosolic pool of DFF40/CAD endonuclease. J Biol Chem. 2012 Mar 2;287(10):7766-79. Group Web site