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principal investigator :
Jose R Bayascas
joseramon.bayascas@uab.cat
Department:
Departament de Bioquímica i biologia Molecular
Unitat de Bioquímica de Medicina
Center:
Institut de Neurociències
Institution:
UAB (Universitat Autònoma de Barcelona)
Members: 4
Research lines:
The role of the PDK1 signalling pathway in neuronal survival: Generation of neuronal-specific PDK1 conditional knock-in mice
Areas:
Central Nervous System Disorders
Signalling
Development
Cognition
Keywords:
PI3K, PDK1, PKB/Akt, neuronal survival and diferentiation, knock-in mice, mental disease
Publications:
Zurashvili T, Cordón-Barris L, Ruiz-Babot G, Zhou X, Lizcano JM, Gómez N, Giménez-Llort L, Bayascas JR.
Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation, but dispensable for neuronal survival.
Mol Cell Biol. 2013 Mar;33(5):1027-40.
Bayascas JR.
PDK1: the major transducer of PI 3-kinase actions.
Curr Top Microbiol Immunol. 2010; 346: 9-29.
Bayascas JR.
Dissecting the role of the 3-phosphoinositide-dependent protein kinase-1 (PDK1) signalling pathways.
Cell Cycle. 2008 Oct;7(19):2978-82.
Group Web site
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