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Neuroinflammation and Oxidative Stress Group

principal investigator : Juan Hidalgo Juan.Hidalgo@uab.es Department: Biologia Cel·lular, Fisiologia i Immunologia / Fisiologia Animal Center: Facultat de Biociències - Institut de Neurociències Institution: UAB (Universitat Autònoma de Barcelona) Members: 5 Research lines: Neuroinflammation and oxidative stress in animal models of multiple sclerosis, Alzheimer's and Trauma Areas:  Central Nervous System Disorders   Neuronal death   Glial cells  Keywords: IL-6, metallothionein, neuroinflammation, Alzheimer's disease, multiple sclerosis, EAE, trauma, transgenic mice Publications: 1. Molnarfi N, Schulze-Topphoff U, Weber MS, Patarroyo JC, Prod’homme T, Varrin-Doyer M, Shetty A, Linington C, Slavin AJ, Hidalgo J, Jenne DE, Wekerle H, Sobel RA, Bernard CCA, Shlomchik MJ, Zamvil SS. MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies. J. Exp. Med. 210 (2013) 2921-2937.   2. Giralt M, Ramos R, Quintana A, Ferrer B, Erta M, Castro-Freire M, Comes G, Sanz E, Unzeta M, Pifarré P, García A, Campbell IL, Hidalgo J. Induction of atypical EAE mediated by transgenic production of IL-6 in astrocytes in the absence of systemic IL-6. Glia 61 (2013) 587-600.   3. Quintana A, Erta M, Ferrer B, Comes G, Giralt M, Hidalgo J. Astrocyte-specific deficiency of interleukin-6 and its receptor reveal specific roles in survival, body weight and behaviour. Brain, Behav. Immun. 27 (2013) 162-173. Group Web site