Neuropharmacology and Pain

principal investigator :

Francisco Ciruela
fciruela@ub.edu

Department:

Unitat de Farmacologia, Departament de Patologia i Terapèutica Experimeltal

Center:

Facultat de Medicina-Bellvitge

Institution:

Universitat de Barcelona (UB)

Members: 12

Research lines:

Oligomerization of G protein-coupled receptors and neurological diseases.

Areas:

 Central Nervous System Disorders   Neurotransmission   Signalling 

Keywords:

GPCR, Parkinsons's disease, Pain, Receptor oligomerization, Neuropharmacology, Dopamine, Adenosine, Glutamate, ion channels

Publications:

1. Ciruela, F., Vilardaga, J.P. and Fernández-Dueñas. V. (2010). Lighting up multiprotein complexes: lessons from GPCR oligomerization. Trends in Biotechnology 28 (8), 407-415. 

2. Vallano, A., Fernández-Dueñas, V., García-Negredo, G., Quijada, M.A., Simón, C.P., Cuffí, M.L., Carbonell, L., Sánchez, S., Arnau, J.M. and Ciruela, F.(2013). Targeting metabotropic glutamate receptror type 5 in Parkinson’s disease: bridging molecular studies and clinical trials. CNS and Neurological Disorders-Drug Targets 12 (8), . 

3. Gómez-Soler, M., Fernández-Dueñas, V., Portillo-Salido, E., Pérez, P., Zamanillo, D., Vela, J.M., Burgueño, J. and Ciruela, F. (2014). Predicting the antinociceptive efficacy of sigma-1 receptor ligands by a novel receptor FRET-based biosensor. Journal of Medicinal Chemistry (In press).

Group Web site


 

IEC  SCB  INC-UAB  UAB

Institut d'Estudis Catalans. Carrer del Carme 47. 08001 Barcelona.
Telèfon +34 933 248 584. Fax +34 932 701 180. scb@iec.cat

- 2014 -



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