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Molecular Neuropharmacology Group

principal investigator : Olga Pol opol@santpau.es Department: Center: Institut d'Investigació Biomèdica Sant Pau-IIB Sant Pau and Institut de Neurociències-UAB Institution: Institut d'Investigació Biomèdica Sant Pau - UAB (Universitat Autònoma de Barcelona) Members: 4 Research lines: Identification of novel therapeutic strategies for chronic pain treatment induiced by lesion, inflammation and/or disease Areas:  Central Nervous System Disorders   Neurotransmission   Signalling  Keywords: analgesia, pain, opioid receptors, cannabinoid receptors, nitric oxide, carbon monoxide, inflammation, nerve injury, diabetes Publications: Hervera A, Leánez S, Motterlini R, Pol O. Treatment with carbon monoxide-releasing molecules and an HO-1 inducer enhances the effects and expression of µ-opioid receptors during neuropathic pain. Anesthesiology. 2013, 118:1180-1197 .  Negrete R, Hervera A, Leánez S, Martín-Campos JM, Pol O. The antinociceptive effects of JWH-015 in chronic inflammatory pain are produced by nitric oxide-cGMP-PKG-KATP pathway activation mediated by opioids. PLoS ONE. 2011, 6: e26688 •  Hervera A, Negrete R, Leánez S, Martín-Campos JM, Pol O. The role of nitric oxide in the local antiallodynic and antihyperalgesic effects and expression of delta-opioid and cannabinoid-2 receptors during neuropathic pain in mice. Journal of Pharmacology and Experimental Therapeutics. 2010, 334:887-896 Group Web site