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Histology and Neurobiology Unit

principal investigator : Josep Tomas - Manel Santafe - Angel Lanuza josepmaria.tomas@urv.net; manuel.santafe@urv.cat Department: Ciències Mèdiques Bàsiques Center: Facultat de Medicina i Ciències de la Salut de Reus Institution: Universitat Rovira i Virgili (URV) Members: 6 Research lines: Neuromuscular neurotransmission; Development of the peripheral nervous system Areas:  Neurotransmission   Development  Keywords: Neuromuscular juncion; ACh Release;calcium channels; muscarinic autoreceptors; purinergic autoreceptors; Serin kinases; peripheral nervous system development;Peripheral nerve diseases;neurotrophic factors Publications: Santafé, M.M.; Sabaté, M.M.; Garcia, N.; Ortiz, N.; Lanuza, M.A.; Tomas, J. 2005. Changes in the neuromuscular synapse induced by an antibody against gangliosides. Annals of Neurology, 57(3): 396-407.  Garcia, N.; Santafé, M.M.; Tomàs, M.; Lanuza, M.A.; Tomàs, J.. 2008. Short-term effects of beta-amyloid(25-35) peptide aggregates on transmitter release in neuromuscular synapses. Journal of Neuropathology and Experimental Neurology, 67(3): 250-258.  Garcia, N.; Tomàs, M.; Santafé, M.M.; Besalduch, N.; Lanuza, M.A.; Tomàs, J. 2010. The interaction between tropomyosin-related kinase B receptors and presynaptic muscarinic receptors modulates transmitter release in adult rodent motor nerve terminals. Journal of Neuroscience, 30(49): 16514-16522