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Lipid Metabolism and Cell Death

principal investigator : Enrique Claro Enrique.Claro@uab.cat Department: Institut de Neurociències Center: Institution: UAB (Universitat Autònoma de Barcelona) Members: 3 Research lines: Cytoprotective role of intracellular lipid droplets Areas:  Central Nervous System Disorders   Signalling   Neuronal death  Keywords: lipid droplets, fatty acid, beta oxidation, phospholipase A2, perilipin, nutrient deprivation Publications: A.G. Cabodevilla, L. Sánchez-Caballero, E. Nintou, V. Voiadjieva, F. Picatoste, A. Gubern, E. Claro (2013) Cell survival during complete nutrient deprivation depends on lipid droplet-fueled and#946;-oxidation of fatty acids. J. Biol. Chem. 288, 27777-27788.  A. Gubern, M. Barceló-Torns, D. Barneda, J.M. López, R. Masgrau, F. Picatoste, C.E. Chalfant, J. Balsinde, M.A. Balboa, E. Claro (2009) JNK and ceramide kinase govern the biogenesis of lipid droplets through activation of GroupIVA phospholipase A2. J. Biol. Chem. 284, 32359-32369.  A. Gubern, M. Barceló-Torns, D. Barneda, R. Masgrau, F. Picatoste, J. Casas, J. Balsinde, M.A. Balboa, E. Claro (2009) Lipid droplet biogenesis induced by stress involves triacylglycerol synthesis that depends on Group VIA phospholipase A2. J. Biol. Chem. 284, 5697-5708.  A. Gubern, J. Casas, M. Barceló-Torns, D. Barneda, X. de la Rosa, R. Masgrau, F. Picatoste, J. Balsinde, M.A. Balboa, E. Claro (2008) Group IVA phospholipase A2 is necessary for the biogenesis of lipid droplets. J. Biol. Chem. 283, 27369-27382.