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Experimental Neuromuscular Pathology

principal investigator : Josep E. Esquerda - Jordi Calderó josep.esquerda@cmb.udl.es Department: Medicina Experimental Center: Facultat de Medicina/IRBLLEIDA Institution: Universitat de Lleida Members: 7 Research lines: Pathogenetic mechanisms and therapy strategies in motor neuron disease (ALS and Spinal Muscular Atrophy). Areas:  Central Nervous System Disorders   Neurotransmission   Signalling   Development   Neuronal death   Glial cells  Keywords: Spinal cord, Motoneuron, Muscle, Neuromuscular junction, Synapse, Neurodegeneration, Neuroinflammation, Amiotrofic Lateral Sclerosis, Spinal Muscular atrophy, Transgenic mouse models. Publications: 1. Sábado J, Casanovas A, Hernández S, Piedrafita L, Hereu M, Esquerda JE. (2013)Immunodetection of disease-associated conformers of mutant cu/zn superoxide dismutase 1 selectively expressed in degenerating neurons in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol. 72:646-61.  2. Dachs E, Hereu M, Piedrafita L, Casanovas A, Calderó J, Esquerda JE.(2011) neuromuscular junction organization and postnatal myogenesis in mice with severe spinal muscular atrophy. J Neuropathol Exp Neurol.70:444-61. 3. Hernández S, Texidó L, Calderó J, Ciutat D, Piedrafita L, Casanovas A, Blasi J, Solsona C, Povedano M, Rojas R, Illa I, Caress J, Prevette D, Oppenheim RW, Milligan C, Esquerda JE. (2010) Increased intramuscular nerve branching and inhibition of programmed cell death of chick embryo motoneurons by immunoglobulins from patients with motoneuron disease. J Neuroimmunol. 229:157-68.