Neural Development
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principal investigator :
Soledad Alcántara
salcantara@ub.edu
Department:
Unitat de Biologia Cel·lular Dept. Patologia i Terapèutica Experimental
Center:
Facultat de Medicina
Institution:
Universitat de Barcelona (UB)
Members: 4
Research lines:
BDNF-regulated genes involved in neurogenesis, growth, migration, differentiation and synaptogenesis in the genes. Functions of these genes during normal development and possible implications in neurodevelopmental human disorders (autistic spectrum disorders, early epileptic encephalopathies, acquired perinatal damage (hypoxia / ischemia, IUGR)). Regulation of the neurovascular niche in the CNS. Development of biomaterials with the capacity to promote CNS regeneration.
Areas:
Central Nervous System Disorders
Signalling
Development
Biomateriales para la regeneración del SNC
Keywords:
CNS regeneration, Biomaterials, Growth factors, neurogenesis, gliogenesis, brain development, synaptogenesis, neuronal migration,
Publications:
Álvarez Z, Mateos-Timoneda MA, Hyroššová P, Castaño O, Planell JA, Perales JC, Engel E, Alcántara S (2013) The effect of the composition of PLA films and lactate release on glial and neuronal maturation and the maintenance of the neuronal progenitor niche. Biomaterials, 34: 2221-2233.
Mattotti M, Alvarez Z, Ortega JA, Planell JA, Engel E and Alcántara S (2012) Inducing functional radial glia-like progenitors from cortical astrocyte cultures using micropatterned PMMA. Biomaterials, 33:1759-1770.
Ortega JA and Alcántara S (2010) BDNF/MAPK/ERK-Induced BMP7 Expression in the Developing Cerebral Cortex Induces Premature Radial Glia Differentiation and Impairs Neuronal Migration. Cerebral Cortex, 20:2132-2144
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