ForewordData summaryMapListSearchCreditsCatalà

 

Neurobiology of Alzheimer's Disease

principal investigator : Carlos A. Saura Carlos.Saura@uab.cat Department: Dep Bioquímica i Biologia Molecular/Institut de Neurociències Center: Institut de Neurociències Institution: UAB (Universitat Autònoma de Barcelona) Members: 6 Research lines: Molecular mechanisms involved in synaptic dysfunction and memory loss in Alzheimer's disease Areas:  Central Nervous System Disorders   Neurotransmission   Signalling  Keywords: Alzheimer´s disease, memory, neurodegeneration,synapse, presenilin, amyloid, CREB, gene expression Publications: España J., Valero J., Miñano A., Masgrau R., Martin E., Guardia-Laguarta C., Lleó A., Giménez-Llort L., Rodríguez-Alvarez J. and Saura C.A. and#946;-Amyloid disrupts activity-dependent gene transcription required for memory through the CREB coactivator CRTC1 (2010). J. Neurosci. 30(28): 9402-10 -  España J., Giménez-Llort L., Valero Gómez-Lobo J., Miñano A., Rábano A., Rodríguez-Alvarez J., LaFerla F.M. and Saura C.A. Intraneuronal Aand#946; accumulation in the amygdala enhances fear and anxiety in Alzheimer’s disease transgenic mice (2010). Biol. Psychiatry 67(6): 513-521.  Valero J., España J., Parra-Damas A., Martin E., Rodríguez-Alvarez J. and Saura C.A. Short-term environmental enrichment rescues adult neurogenesis and memory deficits in APPSw,Ind transgenic mice (2011). PloS ONE 6(2) e16832 Group Web site