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Astrolab

principal investigator : Elena Galea - Roser Masgrau e.galea@uab.es Department: Departament de Bioquímica i Biologia Molecular. Unitat de Bioquímica de Medicina. Institut de Neurociències Center: Facultat de Medicina Institution: UAB (Universitat Autònoma de Barcelona) Members: 5 Research lines: Role of astrocytes in synaptic transmission and in processes related to learning and memory in both normal brain and neurodegenerative diseases Areas:  Central Nervous System Disorders   Neurotransmission   Signalling   Neuronal death   Glial cells  Keywords: astrocytes, calcium signaling, CREB, inflammation, mitochondrial metabolism, cell death, Alzheimer,adrenoleukodystrophy. Publications: ATP and noradrenaline activate CREB in astrocytes via noncanonical Ca(2+) and cyclic AMP independent pathways. Carriba P, Pardo L, Parra-Damas A, Lichtenstein MP, Saura CA, Pujol A, Masgrau R, Galea E. Glia. 2012 Sep;60(9):1330-44. doi: 10.1002/glia.22352. Epub 2012 May 16. NAADP mediates ATP-induced Ca2+ signals in astrocytes.  Barceló-Torns M, Lewis AM, Gubern A, Barneda D, Bloor-Young D, Picatoste F, Churchill GC, Claro E, Masgrau R. FEBS Lett. 2011 Jul 21;585(14):2300-6. doi: 10.1016/j.febslet.2011.05.062. Epub 2011 Jun 6. Altered distribution of RhoA in Alzheimer's disease and AbetaPP overexpressing mice.  Huesa G, Baltrons MA, Gómez-Ramos P, Morán A, García A, Hidalgo J, Francés S, Santpere G, Ferrer I, Galea E. J Alzheimers Dis. 2010;19(1):37-56. doi: 10.3233/JAD-2010-1203. Group Web site