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Pharmacological Modulation of Neurotoxic Amphetamine Derivatives

principal investigator : David Pubill - Jordi Camarasa - Elena Escubedo d.pubill@ub.edu Department: Unitat de Farmacologia i Farmacognòsia. Departament de Farmacologia i Química Terapèutica. Center: Facultat de Farmàcia Institution: Universitat de Barcelona (UB) Members: 7 Research lines: Amphetamine interactions with nicotinic receptors Areas:  Neurotransmission   Neuronal death   Cognition   Addicció  Keywords: cathinones, MDMA, nicotinic acethylcholine receptors, mephedrone, methylone, neurotoxicity, conditioned place preference Publications: Ciudad-Roberts,A., Camarasa,J., Pubill,D., Escubedo,E., 2013. Heteromeric nicotinic receptors are involved in the sensitization and addictive properties of MDMA in mice. Prog. Neuropsychopharmacol. Biol. Psychiatry 44, 201-209.  Lopez-Arnau,R., Martinez-Clemente,J., Pubill,D., Escubedo,E., Camarasa,J., 2012. Comparative neuropharmacology of three psychostimulant cathinone derivatives: butylone, mephedrone and methylone. Br.J.Pharmacol. 167, 407-420.  Garcia-Rates,S., Camarasa,J., Sanchez-Garcia,A.I., Gandia,L., Escubedo,E., Pubill,D., 2010. The effects of 3,4-methylenedioxymethamphetamine (MDMA) on nicotinic receptors: intracellular calcium increase, calpain/caspase 3 activation, and functional upregulation. Toxicol.Appl.Pharmacol. 244, 344-353. Group Web site