ForewordData summaryMapListSearchCreditsCatalà

 

Molecular Mechanisms of Neuronal Death in Neurodegeneration

principal investigator : Cristina Malagelada cristina.malagelada@ub.edu Department: Anatomia Patològica, Farmacologia i Microbiologia Center: Facultat de Medicina Institution: UB (Universitat de Barcelona), IDIBAPS Members: 3 Research lines: mTOR is a serine / threonine kinase that coordinates anabolic and catabolic processes in the cell as a response to cellular events such as nutrient levels, the availability of energy or stress. mTOR and its signaling pathways have been described mainly in non-neuronal cells. Areas:  Central Nervous System Disorders   Neurotransmission   Signalling   Development   Neuronal death  Keywords: Parkinson mTOR Akt RTP801 neuronal death neurodegeneration Publications: Sun X, Liu J, Crary JF, Malagelada C, Sulzer D, Greene LA, Levy OA. ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkin. J Neurosci. 2013 Feb 6;33(6):2398-407.   Greene LA, Levy O, Malagelada C. Akt as a victim, villain and potential hero in Parkinson's disease pathophysiology and treatment. Cell Mol Neurobiol. 2011 Oct;31(7):969-78.   Malagelada C, López-Toledano MA, Willett RT, Jin ZH, Shelanski ML, Greene LA. RTP801/REDD1 regulates the timing of cortical neurogenesis and neuron migration. J Neurosci. 2011 Mar 2;31(9):3186-96. Group Web site