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Alzheimer´s Disease, Stroke, Oxidative Stress, Oxidases

principal investigator : Mercedes Unzeta Mercedes.Unzeta@uab.es Department: BIOQUIMICA Y BIOLOGIA MOLECULAR Center: FACULTAT DE MEDICINA Institution: UAB (Universitat Autònoma de Barcelona) Members: 4 Research lines: Neurodegeneration and aging Areas:  Central Nervous System Disorders   Neuronal death  Keywords: ALZHEIMER´S DISEASE, STROKE, OXIDATIVE STRESS, OXIDASES, NEUROPROTECTION, DESIGN NEW MOLECULES, POLYPHENOLS AND DIET AND AGING Publications: •Anti-apoptotic effect of MAO B inhibitor PF 9601N [N-(2-propynyl)-2-5-benzyloxy-indolyl, methylamine] is mediated by p53 pathway inhibtion in MPP+ treated SH-SY5Y human dopaminergic cells. Sanz E, Quintana A, Battaglia V, Toninello A , Hidalgo J, Ambrosio S, Valoti M , Marco JL, Tipton KF , Unzeta M J neurochem 2008, Jun 1: 105(6):2404-17 IF 4,50 Q1 ,   •Plasma VAP-1/SSAO activity predicts intracranial hemorrhages and adverse neurological outcopme after tissue plasminogen activator treatment in stroke Hernandez-Guillamon M, Garcia-Bonilla L, Sole M, Sosti V, parés M, Campos M, Ortega-Aznar A, Dominguez C, Rubiea M, Ribó M, Quinatna M, Molina CA, Alvarez-Sabin J, Rosell A, Unzeta M, Montaner J Stroke 2010 Jul 41(7) : 1528-35 IF 5.73 Q1  •P53 phosphoryation is involved in vascular cell death induced by the catalytic activity of membrane-bound SSAO/VAP-1 Sole M, Hernandez-Guillamon M, Boada M, Unzeta M Biochim Biophys Acta 2008 Jun; 1783(6):1085-94 IF 4.89 Q1 ISSN:0167-4889 Group Web site