Studies on memory function and biochemical markers of Alzheimer's disease in healthy population and in subjects with cognitive complaints, mild cognitive impairment and prodromal and initial Alzheimer's disease.
Characterization and genetic diagnosis of patients with dementia and family genetic counseling in these families (PICOGEN program). Study of presymptomatic phases of the disease in individuals carrying mutations.
Characterization and diagnosis through biomarkers of early-onset dementia patients (<65 years)
Characterization and diagnosis of Alzheimer's or dementia-not atypical: frontotemporal dementia, progressive aphasia, prion diseases.
ALZHEIMER, FRONTOTEMPORAL DEMENTIA, PRIMARY PROGRESSIVE APHASIA, PRION DISEASES, BIOMARKERS, GENETIC DEMENTIA
1: Antonell A, Lladó A, Altirriba J, Botta-Orfila T, Balasa M, Fernández M,Ferrer I, Sánchez-Valle R, Molinuevo JL. A preliminary study of the whole-genome expression profile of sporadic and monogenic early-onset Alzheimer's disease.
Neurobiol Aging. 2013 Jul;34(7):1772-8. doi:10.1016/j.neurobiolaging.2012.12.026. Epub 2013 Jan 28. PubMed PMID: 23369545.
2: Balasa M, Gelpi E, Antonell A, Rey MJ, Sánchez-Valle R, Molinuevo JL, Lladó A;Neurological Tissue Bank/University of Barcelona/Hospital Clínic NTB/UB/HC Collaborative Group. Clinical features and APOE genotype of pathologically proven early-onset Alzheimer disease. Neurology. 2011 May 17;76(20):1720-5.doi:10.1212/WNL.0b013e31821a44dd. PubMed PMID: 21576687.
3: Fortea J, Sala-Llonch R, Bartrés-Faz D, Bosch B, Lladó A, Bargalló N, Molinuevo JL, Sánchez-Valle R. Increased cortical thickness and caudate volume precede atrophy in PSEN1 mutation carriers. J Alzheimers Dis.2010;22(3):909-22. doi: 10.3233/JAD-2010-100678. PubMed PMID: 20858974.
4: Fortea J, Sala-Llonch R, Bartrés-Faz D, Lladó A, Solé-Padullés C, Bosch B,
Antonell A, Olives J, Sanchez-Valle R, Molinuevo JL, Rami L. Cognitively
preserved subjects with transitional cerebrospinal fluid ß-amyloid 1-42 values
have thicker cortex in Alzheimer's disease vulnerable areas. Biol Psychiatry.
2011 Jul 15;70(2):183-90. doi: 10.1016/j.biopsych.2011.02.017. Epub 2011 Apr 23.
PubMed PMID: 21514924.
