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Neurodegenerative Diseases Research Group

principal investigator : Miquel Vila mvila@ir.vhebron.net Department: Center: Vall d'Hebron Institut de Recerca (VHIR) Institution: Vall d'Hebron Institut de Recerca (VHIR) Members: 12 Research lines: Molecular mechanisms of neurodegeneration Areas:  Central Nervous System Disorders   Neuronal death   Glial cells  Keywords: Parkinson's disease, neurodegeneration, neuroprotection, apoptotsis, autophagy, mitochondria, lysosome, inclusions, alpha-synuclein Publications: 1. Recasens A., Dehay B., Bové J., Carballoand#8208;Carbajal I., Dovero S., Pérez A., Fernagut P.O., Blesa J., Parent A., Perier C., Fariñas I, Obeso J.A., Bezard E. and Vila M. Lewy Body extracts from Parkinson’s Disease Brains trigger and#945;and#8208;Synuclein Pathology and Neurodegeneration in Mice and Monkeys. Annals of Neurology (2013) [Epub ahead of print]  2. Perier C., Bender A., Garcíaand#8208;Arumí E., Melià M.J., Bové J., Laub C., Klopstock T., Elstner M., Mounsey R.B., Teismann P., Prolla T., Andreu A.L. and Vila M. Accumulation of mitochondrial DNA deletions within dopaminergic neurons triggers neuroprotective mechanisms. Brain (2013) 136:2369and#8208;78  3. Ramonet D., Perier C., Recasens A., Dehay B., Bové J., Costa V., Scorrano L. and Vila M. Optic atrophy 1 mediates mitochondria remodeling and dopaminergic neurodegeneration linked to complex I deficiency. Cell Death and Differentiation (2013) 20(1):77and#8208;85 Group Web site