ForewordData summaryMapListSearchCreditsCatalà

 

Neurodegeneration and Aging

principal investigator : Coral Sanfeliu coral.sanfeliu@iibb.csic.es Department: isquèmia Cerebral i Neurodegeneració Center: Institut d'Investigacions Biomèdiques de Barcelona (IIBB) Institution: CSIC, IDIBAPS Members: 4 Research lines: Experimental studies of neuroprotection against cognitive decline associated with aging and Alzheimer's disease risk, by activating sirtuin signaling pathways and other survival pathways associated to healthy lifestyle. Areas:  Central Nervous System Disorders   Neuronal death   Cognition  Keywords: aging, neurodegeneration, Alzheimer's disease, healthy life styles, sirtuins Publications: Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse. García-Mesa Y, Giménez-Llort L, López LC, Venegas C, Cristòfol R, Escames G, Acuña-Castroviejo D, Sanfeliu C. Neurobiol Aging. 2012 Jun;33(6):1124.e13-29.  Neurons from senescence-accelerated SAMP8 mice are protected against frailty by the sirtuin 1 promoting agents melatonin and resveratrol. Cristòfol R, Porquet D, Corpas R, Coto-Montes A, Serret J, Camins A, Pallàs M, Sanfeliu C. J Pineal Res. 2012 Apr;52(3):271-81.  Physical exercise protects against Alzheimer's disease in 3xTg-AD mice. García-Mesa Y, López-Ramos JC, Giménez-Llort L, Revilla S, Guerra R, Gruart A, Laferla FM, Cristòfol R, Delgado-García JM, Sanfeliu C. J Alzheimers Dis. 2011;24(3):421-54. Group Web site