Neurobiology of the NMDA Receptor

principal investigator :

Xavier Altafaj
xaltafaj@idibell.cat

Department:

Institut de Neuropatologia

Center:

Hospital Duran i Reynals

Institution:

IDIBELL

Members: 2

Research lines:

Molecular mechanisms involved in the trafficking and activity of NMDA receptors under physiological conditions

Areas:

 Central Nervous System Disorders   Neurotransmission   Cognition 

Keywords:

NMDA receptors, glutamatergic neurotransmission, phosphorylation, DYRK1A, Down syndrome, gene therapy, neurodegeneration, mental retardation.

Publications:

Altafaj X, Martín ED, Ortiz-Abalia J, Valderrama A, Lao-Peregrín C, Dierssen M, Fillat C. "Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome". Neurobiol Dis. 2013, 52:117-27. 

Ortiz-Abalia J, Sahún I, Altafaj X, Andreu N, Estivill X, Dierssen M, Fillat C. "Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome". Am J Hum Genet. 2008, 83(4):479-88. 

Altafaj X, Ortiz-Abalia J, Fernández M, Potier MC, Laffaire J, Andreu N, Dierssen M, González-García C, Ceńa V, Martí E, Fillat C. "Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome". Neurobiol Dis. 2008, 32(3):377-84.


 

IEC  SCB  INC-UAB  UAB

Institut d'Estudis Catalans. Carrer del Carme 47. 08001 Barcelona.
Telèfon +34 933 248 584. Fax +34 932 701 180. scb@iec.cat

- 2014 -



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