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Neurobiology of the NMDA Receptor

principal investigator : Xavier Altafaj xaltafaj@idibell.cat Department: Institut de Neuropatologia Center: Hospital Duran i Reynals Institution: IDIBELL Members: 2 Research lines: Molecular mechanisms involved in the trafficking and activity of NMDA receptors under physiological conditions Areas:  Central Nervous System Disorders   Neurotransmission   Cognition  Keywords: NMDA receptors, glutamatergic neurotransmission, phosphorylation, DYRK1A, Down syndrome, gene therapy, neurodegeneration, mental retardation. Publications: Altafaj X, Martín ED, Ortiz-Abalia J, Valderrama A, Lao-Peregrín C, Dierssen M, Fillat C. "Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome". Neurobiol Dis. 2013, 52:117-27.  Ortiz-Abalia J, Sahún I, Altafaj X, Andreu N, Estivill X, Dierssen M, Fillat C. "Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome". Am J Hum Genet. 2008, 83(4):479-88.  Altafaj X, Ortiz-Abalia J, Fernández M, Potier MC, Laffaire J, Andreu N, Dierssen M, González-García C, Ceña V, Martí E, Fillat C. "Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome". Neurobiol Dis. 2008, 32(3):377-84.