Biochemistry

Berg, Jeremy M.; Tymoczko, John L.; Gatto, Jr., Gregory J.; Stryer, Lubert

8 ed.

New York: W.H. Freeman and Company, 2015

p. 195

The hemoglobin tetramer, referred to as hemoglobin A (HbA), is best described as a pair of identical xalfaxxbetax dimers (xalfax₁xbetax₁ and xalfax₂xbetax₂) that associate to form the tetramer.

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p. 207

The tetramers, referred to as hemoglobin H (HbH), bind oxygen with high affinity and no cooperativity.

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p. 875

For example, heat-shock transcription factor (HSTF) is expressed in Drosophila after an abrupt increase in temperature.

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p. 896

FIGURE 30.5 Helix stacking in tRNA.

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p. 534

A cytochrome is an electron-transferring protein that contains a heme prosthetic group.

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p. 307

An account of a hemorrhagic disposition existing in certain families

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p. 114

4.3 The Double Helix Facilitates the Accurate Transmission of Hereditary Information

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p. 851

For example, hereditary nonpolyposis colorectal cancer (HNPCC, or Lynch syndrome) results from defective DNA mismatch repair.

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p. 389

In particular, the K+ channel hERG (for human ether-a-go-go-related gene, named for its ortholog in Drosophila melanogaster) is highly susceptible to interactions with certain drugs.

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p. 968

FIGURE 33.16 Evidence for a heterodimeric sweet receptor.

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p. 594-595

The mixture of the three phosphorylated hexoses is called the hexose monophosphate pool.

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p. 496

The citric acid cycle harvests high-energy electrons

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p. 9

2. Water is highly cohesive. Water molecules interact strongly with one another through hydrogen bonds.

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p. 155

All of these methods are highly parallel: from 1 million to 1 billion DNA fragment sequences are acquired in a single experiment.

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p. 954

The relacion between various histone modifications and their roles in controlling gene expression is sometimes referred to as "the histone code."

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p. 943

DNA wraps around histone octamers to form nucleosomes

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p. 996

The three-dimensional structure of a large extracellular fragment of a human MHC class I protein, human leukocyte antigen A2 (HLA-A2), was solved in 1987 by Don Wiley and Pamela Bjorkman.

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p. 1013

The treatment of myosin with trypsin and papain results in the formation of four fragments: two S1 fragments; heavy meromyosin (HMM) which consists of the S1 fragments and an additional region termed S2; and a fragment called light meromyosin (LMM; Figure 35.2).

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p. 851

For example, hereditary nonpolyposis colorectal cancer (HNPCC, or Lynch syndrome) results from defective DNA mismatch repair.

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p. 726

High homocysteine levels correlate with vascular diseases

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p. 655

In this homolytic cleavage reaction, one electron of the Co-C bond stays with Co (reducing it from the +3 to the +2 oxidation state), whereas the other electron stays with the carbon atom, generating a free radical.

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p. 179

A case in point is the protein actin, a major component of the cytoskeleton (Section 35.2), and heat shock protein 70 (Hsp70), which assists protein folding inside cells.

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p. 875

For example, heat-shock transcription factor (HSTF) is expressed in Drosophila after an abrupt increase in temperature.

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p. 19

FIGURE 1.21 Human migration supported by DNA sequence comparisons.

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p. 1048

Potential targets can be identified in the human proteome

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p. 328

Formerly called gargoylism, Hurler disease is a mucopolysaccharidosis having symptoms that include wide nostrils, a depressed nasal bridge, thick lips and earlobes, and irregular teeth.

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p. 81

Hybridoma cells can then be screened by a specific assay for the antigen-antibody interaction to determine which ones produce antibodies of the preferred specificity.

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p. 348

Their polar head groups favor contact with water, whereas their hydrocarbon tails interact with one another in preference to water.

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p. 8

The hydrogen-bond donor is the group that includes both the atom to which the hydrogen atom is more tightly linked and the hydrogen atom itself, whereas the hydrogen-bond acceptor is the atom less tightly linked to the hydrogen atom (Figure 1.9).

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p. 441

5.Hydrolytic reactions cleave bonds by the addition of water.

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p. 426

A large amount of free energy is liberated when ATP is hydrolyzed to adenosine diphosphate (ADP) and orthophosphate (P_i) or when ATP is hydrolyzed to adenosine monophosphate (AMP) and pyrophosphate (PP_i).

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p. 47

Some proteins that span biological membranes are "the exceptions that prove the rule" because they have the reverse distribution of hydrophobic and hydrophilic amino acids.

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p. 347

A membrane lipid is an amphipathic molecule containing a hydrophilic and a hydrophobic moiety

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p. 347

A membrane lipid is an amphipathic molecule containing a hydrophilic and a hydrophobic moiety

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p. 202

One treatment for carbon monoxide poisoning is administration of 100% oxygen, often at pressures greater than atmospheric pressure (this treatment is referred to as hyperbaric oxygen therapy).

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p. 948

These hypersensitive sites correspond to regions that have few nucleosomes or contain nucleosomes in an altered conformation.

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p. 513

Defects in these enzymes share a common biochemical link: the transcription factor hypoxia inducible factor 1 (HIF-1).

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